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Bioorg Med Chem Lett. 2001 Jul 23;11(14):1935-8.

alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases.

Author information

1
Department of Chemistry, Brown University, 02912, Providence, RI, USA.

Abstract

A series of aryl alpha-ketocarboxylic acids was synthesized and investigated as inhibitors for the protein tyrosine phosphatase from Yersinia enterocolitica. IC(50) values for these compounds range from 79 to 2700 microM. Larger aromatic groups, and aromatic groups with high electron density, lead to more potent inhibitors. In general, the related aryl alpha-hydroxycarboxylic acids show lower activity.

PMID:
11459664
DOI:
10.1016/s0960-894x(01)00325-0
[Indexed for MEDLINE]

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