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Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10.

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.

Author information

1
GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow, CM19 5AW, Essex, UK. porter@sbphrd.com

Abstract

This communication reports SARs for the first orexin-1 receptor antagonist series of 1-aryl-3-quinolin-4-yl and 1-aryl-3-naphthyridin-4-yl ureas. One of these compounds, 31 (SB-334867), has excellent selectivity for the orexin-1 receptor, blood-brain barrier permeability and shows in vivo activity following ip dosing.

PMID:
11459658
DOI:
10.1016/s0960-894x(01)00343-2
[Indexed for MEDLINE]

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