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Bioorg Med Chem Lett. 2001 Jul 23;11(14):1885-8.

Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.

Author information

1
Global Chemical Sciences and Neuroscience Departments, Wyeth-Ayerst Research Laboratories, CN 8000, NJ 08543-8000, Princeton, USA.

Abstract

A series of indolylcyclohexylamines possessing potent and selective serotonin reuptake inhibition is reported. The most interesting compounds proved to have subnanomolar 5-HT transporter activity, and exhibited moderate 5-HT(1A) affinity.

PMID:
11459653
DOI:
10.1016/s0960-894x(01)00334-1
[Indexed for MEDLINE]

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