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Curr Opin Nephrol Hypertens. 2001 Jul;10(4):523-31.

Evolving strategies for renoprotection: non-diabetic chronic renal disease.

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Renal Unit, Nottingham City Hospital, Hucknall Road, Nottingham, UK.


Experimental and clinical studies over the past two decades have identified several interventions for slowing the progression of chronic renal disease towards end-stage renal failure. In this paper we review the experimental and clinical evidence in support of dietary protein restriction, angiotensin-converting enzyme inhibitor therapy, control of systemic hypertension, reduction of proteinuria, treatment of hyperlipidemia and smoking cessation. We also consider potential future renoprotective therapies. Finally we propose a comprehensive strategy for achieving maximal renoprotection with available interventions and monitoring.

[Indexed for MEDLINE]

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