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Neurosci Lett. 2001 Aug 3;308(2):87-90.

Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum.

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Department of Pharmacology, Oita Medical University, 1-1, Hasama-machi, Oita 879-5593, Japan.


We examined whether tamoxifen could suppress 1-methyl-4-phenylpyridine (MPP(+))-induced hydroxyl radical generation in the extracellular fluid of rat striatum, using in vivo microdialysis system. MPP(+) (5 mM) enhanced generation of hydroxyl radicals with concomitant increased efflux of dopamine. Tamoxifen (1--100 microM) dose-dependently suppressed the hydroxyl radical formation induced by MPP(+). Tamoxifen (100 microM) significantly attenuated dopamine efflux induced by MPP(+). The result in the present study is the first demonstration showing the protective effect of tamoxifen on hydroxyl radical generation induced by MPP(+) by suppressing dopamine efflux.

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