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Heart. 2001 Aug;86(2):212-6.

Magnesium causes nitric oxide independent coronary artery vasodilation in humans.

Author information

1
The First Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima, Japan 734-8851. teragawa@mcai.med.hiroshima-u.ac.jp

Abstract

OBJECTIVE:

To determine how magnesium affects human coronary arteries and whether endothelium derived nitric oxide (EDNO) is involved in the coronary arterial response to magnesium.

DESIGN:

Quantitative coronary angiography and Doppler flow velocity measurements were used to determine the effects of the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on magnesium induced dilation of the epicardial and resistance coronary arteries.

SETTING:

Hiroshima University Hospital a tertiary cardiology centre.

PATIENTS:

17 patients with angiographically normal coronary arteries.

INTERVENTIONS:

Magnesium sulfate (MgSO(4)) (0.02 mmol/min and 0.2 mmol/min) was infused for two minutes into the left coronary ostium before and after intracoronary infusion of L-NMMA.

MAIN OUTCOME MEASURES:

Diameter of the proximal and distal segments of the epicardial coronary arteries and coronary blood flow.

RESULTS:

At a dose of 0.02 mmol/min, MgSO(4) did not affect the coronary arteries. At a dose of 0.2 mmol/min, MgSO(4) caused coronary artery dilation (mean (SEM) proximal diameter 3.00 (0.09) to 3.11 (0.09) mm; distal 1.64 (0.06) to 1.77 (0.07) mm) and increased coronary blood flow (79.3 (7.5) to 101.4 (9.9) ml/min, p < 0.001 v baseline for all). MgSO(4) increased the changes in these parameters after the infusion of L-NMMA (p < 0.001 v baseline).

CONCLUSIONS:

Magnesium dilates both the epicardial and resistance coronary arteries in humans. Furthermore, the coronary arterial response to magnesium is dose dependent and independent of EDNO.

PMID:
11454846
PMCID:
PMC1729866
[Indexed for MEDLINE]
Free PMC Article
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