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Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9.

Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor.

Author information

1
Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA, Leiden, The Netherlands.

Abstract

The synthesis and receptor binding of novel adenosine receptor antagonists is described. We found that non-xanthine 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives may have high affinity and substantial selectivity for the adenosine A(1) receptor.

PMID:
11454470
DOI:
10.1016/s0960-894x(01)00356-0
[Indexed for MEDLINE]

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