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Curr Opin Cell Biol. 2001 Aug;13(4):485-92.

The role of phosphoinositides in membrane transport.

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Department of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway.


Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking. Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent results show that regulated synthesis and turnover of phosphoinositides by membrane-associated phosphoinoside kinases and phosphatases spatially restrict the location of effectors critical for cellular transport processes, such as clathrin-mediated endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking.

[Indexed for MEDLINE]

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