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Curr Opin Cell Biol. 2001 Aug;13(4):412-6.

Protein export and drug efflux through bacterial channel-tunnels.

Author information

1
Cambridge University Department of Pathology, Tennis Court Road, CB2 1QP, Cambridge, UK.

Abstract

The bacterial protein TolC assembles into an alpha-helical trans-periplasmic tunnel, which is embedded in the outer membrane by a contiguous beta-barrel channel. TolC and its homologues thus provide large exit ducts for a wide range of substrates, including protein toxins and antibacterial drugs, that are engaged by specific recognition proteins in the cytosolic membrane.

PMID:
11454445
DOI:
10.1016/s0955-0674(00)00229-5
[Indexed for MEDLINE]

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