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Cancer Genet Cytogenet. 2001 Jul 1;128(1):39-42.

Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies.

Author information

1
Center for Medical Genetics, De Pintelaan 185, B-9000 Gent, Belgium.

Abstract

Bloom syndrome (BS) predisposes affected individuals to a wide variety of neoplasms including hematological malignancies. Thus far, cytogenetic findings in hematological neoplasms have been reported in only a few BS patients. We present the karyotypic findings in a BS patient diagnosed with acute myeloid leukemia (AML), FAB subtype M1, and a review of the literature, showing the preferential occurrence of total or partial loss of chromosome 7 in BS patients with AML or myelodysplastic syndromes (MDS).

PMID:
11454428
DOI:
10.1016/s0165-4608(01)00392-2
[Indexed for MEDLINE]

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