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Cell Res. 2001 Jun;11(2):89-94.

The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes.

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  • 1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai.

Abstract

We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-beta1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-beta1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-beta1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-beta1-mediated gene expression and apoptosis.

PMID:
11453551
DOI:
10.1038/sj.cr.7290072
[PubMed - indexed for MEDLINE]
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