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Br J Psychiatry Suppl. 2001 Jun;41:s169-76.

The Stanley Foundation Bipolar Network. I. Rationale and methods.

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1
National Institute of Mental Health, Bethesda, Maryland, USA.

Abstract

BACKGROUND:

The Stanley Foundation Bipolar Network (SFBN) was created to address the paucity of help studies in bipolar illness.

AIMS:

To describe the rationale and methods of the SFBN.

METHOD:

The SFBN includes five core sites and a number of affiliated sites that have adopted consistent methodology for continuous longitudinal monitoring of patients. Open and controlled studies are performed as patients' symptomatology dictates.

RESULTS:

The reliability of SFBN raters and the validity of the rating instruments have been established. More than 500 patients are in continuous daily longitudinal follow-up. More than 125 have been randomised to one of three of the newer antidepressants (bupropion, sertraline and venlafaxine) as adjuncts in a study of mood stabilizers and 93 to omega-3 fatty acids. A number of open clinical case series have been published.

CONCLUSIONS:

Well-characterised patients are followed in a detailed continuous longitudinal fashion in both opportunistic case series and double-blind, randomised controlled trials with reliable and validated measures.

PMID:
11450179
[Indexed for MEDLINE]
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