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Arq Bras Cardiol. 2001 Jun;76(6):463-72.

Diet and medication in the treatment of hyperuricemia in hypertensive patients.

[Article in English, Portuguese]

Author information

  • 1Faculdades de Medicina Enfermagem e Nutrição, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Abstract

OBJECTIVE:

To evaluate the effects of diet and medication, either isolated or associated, on serum levels of uric acid in patients with hyperuricemia.

METHODS:

We studied patients from the Hypertension Unit of the University of Goias who had hyperuricemia (men > or =8.5 mg/dL and women > or =7.5 mg/dL). We divided the patients into three groups: G1 (low purine diet), G2 (low purine diet + medication), and G3 (medication only). Patients received allopurinol, 150 mg/day titrated up to 300 mg/dL when necessary. Patients were evaluated with regards to their lifestyles (diet, smoking, physical, activity, alcohol consumption), uric acid, blood pressure, use of medication, body mass index, cholesterol, and triglyceride. Follow-up took place in weeks 0 (M1), 6 (M2), 12 (M3) during the intervention and in week 36 (M4) after the study was completed.

RESULTS:

Fifty-five patients participated in the study, 31 women, mean age 54.4+/-10.6 years, body mass index 28.6+/-3.9 kg/m2. A similar reduction (p<0.001) in uric acid levels occurred in the three intervention groups. In week 36 (M4), after 24 weeks without intervention, a tendency toward elevation of uricemia was noted in G2 and G3, and a continuous drop in uricemia was noted in G1. No significant modifications were observed in the other variables analyzed.

CONCLUSION:

Considering the cost x benefit relationship, a diet low in purine should be the 1st therapeutic option for controlling hyperuricemia in patients with similar characteristic to the ones presented in this study.

PMID:
11449292
[PubMed - indexed for MEDLINE]
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