Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 2001 Jul 12;412(6843):143-4.

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats.

Author information

1
MRC Laboratory of Molecular Biology, Cambridge, UK.

Abstract

Neurodegenerative diseases resulting from expanded repeat sequences of glutamine residues are associated with the formation of protein aggregates in the cell nuclei of the affected neurons, but whether these are pathogenic is controversial. Recent observations indicate that the ages of onset of these diseases are exponential functions of the repeat lengths and that the probability of neural death is constant with time. The only process known to us that could give rise to such behaviour is nucleation of the aggregates.

PMID:
11449262
DOI:
10.1038/35084141
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center