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Curr Opin Genet Dev. 2001 Aug;11(4):374-83.

Axis formation during Drosophila oogenesis.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrabetae 1, Postfach10.2209, D-69012, Heidelberg, Germany. riechman@embl-heidelberg.de

Abstract

Recent advances shed light on the cellular processes that cooperate during oogenesis to produce a fully patterned egg, containing all the maternal information required for embryonic development. Progress has been made in defining the early steps in oocyte specification and it has been shown that progression of oogenesis is controlled by a meiotic checkpoint and requires active maintenance of the oocyte cell fate. The function of Gurken signalling in patterning the dorsal-ventral axis later in oogenesis is better understood. Anterior-posterior patterning of the embryo requires activities of bicoid and oskar mRNAs, localised within the oocyte. A microtubule motor, Kinesin, is directly implicated in localisation of oskar mRNA to the posterior pole of the oocyte.

PMID:
11448623
DOI:
10.1016/s0959-437x(00)00207-0
[Indexed for MEDLINE]

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