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Curr Opin Genet Dev. 2001 Aug;11(4):367-73.

Axis determination in C. elegans: initiating and transducing polarity.

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Wellcome/CRC Institute, Tennis Court Road, CB2 1QR, Cambridge, UK.


The anterior-posterior axis in Caenorhabditis elegans is determined by the sperm and leads to the asymmetric localisation of PAR (partitioning-defective) proteins, which are critical for polarity. New findings demonstrate that sperm asters play a critical role and suggest models for how PAR asymmetry is established. In addition, studies of blastomere fate determination and heterotrimeric G proteins have started to uncover how initial polarity may be translated into the asymmetric distribution of maternal proteins and the control of spindle position.

[Indexed for MEDLINE]

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