Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2001 Jul 20;12(10):2251-4.

Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study.

Author information

  • 1Department of Clinical Neuroscience, Human Brain Informatics, Psychiatry Section, and 1MR Center, Karolinska Institute, SE-171 76 Stockholm, Sweden.


Fractional anisotropy and the mean diffusion coefficient were measured in the cerebral volume in 20 schizophrenic and 24 healthy subjects, men and women, using diffusion tensor imaging. In addition, 3D SPGR was used for segmentation of brain tissue into grey and white matter and cerebrospinal fluid. In schizophrenic patients, fractional anisotropy was reduced in the splenium of the corpus callosum and in adjacent occipital white matter. The segmentation revealed no tissue deficits in the volume of reduced fractional anisotropy. The mean diffusion was increased in the total white and grey matter volume of the schizophrenic patients compared with the healthy subjects. The findings support the view that global and regional white matter abnormalities occur in chronic schizophrenia.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center