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J Hypertens. 2001 Jul;19(7):1209-15.

Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey.

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1
Department of Preventive Medicine and Environmental Health, Osaka City General Hospital, Japan.

Abstract

OBJECTIVE:

To investigate the association of serum uric acid level with the risk for hypertension and Type 2 diabetes.

DESIGN:

Prospective cohort study.

SETTING:

Work site in Osaka, Japan.

PARTICIPANTS:

A total of 6,356 Japanese men, aged 35-60 years with systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg, normal glucose intolerance, and no history of hypertension or diabetes at baseline.

MAIN OUTCOME MEASURES:

Blood pressure was measured by standard techniques, using 160/95 mmHg for diagnosis of hypertension. Type 2 diabetes was defined as a fasting plasma glucose level > or = 126 mg/dl or a 2 h post-loaded plasma glucose level > or = 200 mg/dl.

RESULTS:

During the 61,716 person-years follow-up period, we confirmed 639 cases of hypertension and 454 cases of Type 2 diabetes. Serum uric acid level was associated with an increased risk for hypertension but not for Type 2 diabetes. After adjustment for known risk factors, including daily alcohol consumption, the serum uric acid level was associated with an increased risk for hypertension; the relative risks for hypertension were 1.00 for quintile 1 of the serum uric acid level, 1.24 [95% confidence interval (CI), 0.94-1.65] for quintile 2, 1.34 (CI, 1.03-1.76) for quintile 3, 1.76 (CI, 1.35-2.29) for quintile 4, and 2.01 (CI, 1.56-2.60) for quintile 5 (P for trend < 0.001). Even among both non-drinkers and lean subjects, serum uric acid level was associated with an increased risk for hypertension.

CONCLUSIONS:

Serum uric acid level was associated with an increased risk for hypertension but not for Type 2 diabetes.

PMID:
11446710
[Indexed for MEDLINE]
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