Format

Send to

Choose Destination
See comment in PubMed Commons below
J Gerontol A Biol Sci Med Sci. 2001 Jul;56(7):B311-23.

Melatonin increases both life span and tumor incidence in female CBA mice.

Author information

1
N. N. Petrov Research Institute of Oncology, St. Petersburg, Russia. aging@mail.ru

Abstract

From the age of 6 months until their natural deaths, female CBA mice were given melatonin with their drinking water (20 mg/l) for 5 consecutive days every month. Intact mice served as controls. The results of this study show that the consumption of melatonin did not significantly influence food consumption, but it did increase the body weight of older mice; it did not influence physical strength or the presence of fatigue; it decreased locomotor activity and body temperature; it inhibited free radical processes in serum, brain, and liver; it slowed down the age-related switching-off of estrous function; and it increased life span. However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice. For this reason, we concluded that it would be premature to recommend melatonin as a geroprotector for long-term use.

PMID:
11445596
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center