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Microbes Infect. 2001 Jul;3(8):655-77.

Immunity to Bordetella pertussis.

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Infection and Immunity Group, Institute of Immunology, Department of Biology, National University of Ireland, Maynooth, Co., Kildare, Ireland.


Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and a variety of immune evasion strategies to prolong its survival in the host. This article reviews evidence of complementary roles for cellular and humoral immunity in protection. It discusses the effector mechanisms of bacterial elimination, the strategies employed by the bacteria to subvert protective immune responses and the immunological basis for systemic and neurological responses to infection and vaccination.

[Indexed for MEDLINE]

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