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Magn Reson Med. 2001 Jul;46(1):1-5.

Parahydrogen-induced polarization in imaging: subsecond (13)C angiography.

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Nycomed Innovation AB, MEDEON, SE-205 12 Malmö, Sweden.


High nuclear spin polarization of (13)C was reached in organic molecules. Enhancements of up to 10(4), compared to thermal polarization at 1.5 T, were achieved using the parahydrogen-induced polarization technique in combination with a field cycling method. While parahydrogen has no net polarization, it has a high spin order, which is retained when hydrogen is incorporated into another molecule by a chemical reaction. By subjecting this molecule to a sudden change of the external magnetic field, the spin order is transferred into net polarization. A (13)C angiogram of an animal was generated in less than a second. Magn Reson Med 46:1-5, 2001.

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