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Am J Hematol. 2001 Aug;67(4):256-8.

Report of three cases of circulating heparin-like anticoagulants.

Author information

1
Hematology and Hemotherapy Department, Fundación Jiménez Díaz, Madrid, Spain. pllamas@fjd.es

Abstract

Clinically significant endogenous circulating heparin-like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin-like anticoagulants is poorly understood. We report three cases of circulating heparin-like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T-prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep-site hematoma to bleeding of biopsy site and occasional ecchymosis.

PMID:
11443639
DOI:
10.1002/ajh.1126
[Indexed for MEDLINE]
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