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J Infect Dis. 2001 Aug 1;184(3):369-72. Epub 2001 Jul 10.

Nosocomial outbreak of multiple bloodborne viral infections.

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1
Laboratory of Virology, Division of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland.

Abstract

In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.

PMID:
11443566
DOI:
10.1086/322036
[Indexed for MEDLINE]
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