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Muscle Nerve. 2001 Aug;24(8):1090-2.

Passive stiffness is increased in soleus muscle of desmin knockout mouse.

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  • 1Unité de Biomécanique et Génie Biomédical, Unité Mixte de Recherche 6600, Centre National de la Recherche Scientifique et Université de Technologie, BP 20529, F-60205 Compiègne, France.


The effects of an absence of desmin on passive stiffness of skeletal muscle were analyzed using soleus muscles from desmin knockout mice. Stiffness was evaluated by analyzing the passive tension induced by a ramp-and-hold extension test. This test showed that passive resistance to stretch was largely increased for muscles lacking desmin. This study could facilitate interpretation of changes in muscle mechanics observed in humans affected by desmin-related myopathies.

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