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Virology. 2001 Jul 5;285(2):346-55.

The NS2 protein generated by the parvovirus minute virus of mice is degraded by the proteasome in a manner independent of ubiquitin chain elongation or activation.

Author information

1
Department of Molecular Microbiology and Immunology, University of Missouri at Columbia School of Medicine, Columbia, Missouri 65212, USA.

Abstract

The NS2 protein generated by the parvovirus minute virus of mice is very labile, having a half-life during infection of approximately 90 min. The degradation of NS2 is blocked by proteasome inhibitors but is likely ubiquitin independent: NS2 does not form detectable higher molecular weight ubiquitin-containing conjugates, and NS2 degradation requires neither ubiquitin chain elongation nor intracellular ubiquitin activation. We have also identified a region in the carboxyl half of NS2 that is required for its proteasome-mediated degradation.

PMID:
11437668
DOI:
10.1006/viro.2001.0966
[Indexed for MEDLINE]
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