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Breast Cancer Res Treat. 2001 Mar;66(2):165-70.

Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors.

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Department of Surgery, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto, Japan.


A fundamental obstacle in cancer gene therapy is the specific targeting of therapy directly to a solid tumor, and no systemic delivery system yet exists. A strain of domestic bacteria, Bifidobacterium longum, which is nonpathogenic and anaerobic, selectively localized to and proliferated in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors after systemic application. We further ascertained the tumor specificity of genetically engineered, as well as wild-type, Bifidobacterium longum. This is the first demonstration that Bifidobacterium longum can be utilized as a specific gene delivery vector for gene therapy on solid breast tumors.

[Indexed for MEDLINE]

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