Format

Send to

Choose Destination
See comment in PubMed Commons below
J Virol. 2001 Aug;75(15):7142-8.

Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity.

Author information

1
Chiron Corporation, Emeryville, California 94608, USA. amy_weiner@chiron.com

Abstract

Naturally occurring hepatitis C virus (HCV) infection has long been thought to induce a weak immunity which is insufficient to protect an individual from subsequent infections and has cast doubt on the ability to develop effective vaccines. A series of intrahepatic genetic inoculations (IHGI) with type 1a HCV RNA were performed in a chimpanzee to determine whether a form of genetic immunization might stimulate protective immunity. We demonstrate that the chimpanzee not only developed protective immunity to the homologous type 1a RNA after rechallenge by IHGI but was also protected from chronic HCV infection after sequential rechallenge with 100 50% chimpanzee infectious doses of a heterologous type 1a (H77) and 1b (HC-J4) whole-virus inoculum. These results offer encouragement to pursue the development of HCV vaccines.

PMID:
11435595
PMCID:
PMC114443
DOI:
10.1128/JVI.75.15.7142-7148.2001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center