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Br J Psychiatry. 2001 Jul;179:23-30.

Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalised social phobia.

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1
Department of Psychosomatic and Behavioural Medicine, National Hospital, Oslo, Norway.

Abstract

BACKGROUND:

No controlled trial of treatment of generalised social phobia has been conducted in general practice.

AIMS:

To examine the efficacy of sertraline or exposure therapy, administered alone or in combination in this setting.

METHOD:

Study was of a randomised, double-blind design. Patients (n = 387) received sertraline 50-150 mg or placebo for 24 weeks. Patients were additionally randomised to exposure therapy or general medical care.

RESULTS:

Sertraline-treated patients were significantly more improved than non-sertraline-treated patients (chi(2)=12.53, P<0.001; odds ratio=0.534; 95% Cl 0.347-0.835). No significant difference was observed between exposure- and non-exposure-treated patients (chi(2)=2.18, P=0.140; odds ratio=0.732; 95% Cl 0.475-1.134). In the pairwise comparisons, combined sertraline and exposure (chi(2)=12.32; P<0.001) and sertraline (chi(2)=10.13; P=0.002) were significantly superior to placebo.

CONCLUSIONS:

Sertraline is an effective treatment for generalised social phobia. Combined treatment with sertraline and exposure therapy, conducted by the general practitioner, may enhance the treatment efficacy in primary care.

PMID:
11435264
DOI:
10.1192/bjp.179.1.23
[Indexed for MEDLINE]

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