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Nat Rev Mol Cell Biol. 2001 Jul;2(7):550-6. doi: 10.1038/35080103.

XIAP, the guardian angel.

Author information

1
Children's Hospital of Eastern Ontario Research Institute, and AEgera Oncology Inc., 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada. martin@mgcheo.med.uottawa.ca

Abstract

Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.

PMID:
11433370
DOI:
10.1038/35080103
[Indexed for MEDLINE]
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