Format

Send to

Choose Destination
Pediatrics. 2001 Jul;108(1):129-33.

Experience with the ketogenic diet in infants.

Author information

1
Epilepsy Center, Children's Memorial Hospital, Chicago, Illinois, USA. dnordli@childrensmemorial.org

Abstract

OBJECTIVE:

To evaluate the effectiveness, tolerability, and adverse effects of the ketogenic diet in infants with refractory epilepsy.

METHODS:

A retrospective review of 32 infants who had been treated with the ketogenic diet at a large metropolitan institution.

RESULTS:

Most infants (71%) were able to maintain strong ketosis. The overall effectiveness of the diet in infants was similar to that reported in the literature for older children; 19.4% became seizure-free, and an additional 35.5% had >50% reduction in seizure frequency. The diet was particularly effective for patients with infantile spasms/myoclonic seizures. There were concomitant reductions in antiepileptic medications. The majority of parents reported improvements in seizure frequency and in their child's behavior and function, particularly with respect to attention/alertness, activity level, and socialization. The diet generally was well-tolerated, and 96.4% maintained appropriate growth parameters. Adverse events, all reversible and occurring in one patient each, included renal stone, gastritis, ulcerative colitis, alteration of mentation, and hyperlipidemia.

CONCLUSION:

The ketogenic diet should be considered safe and effective treatment for infants with intractable seizures.

Comment in

PMID:
11433065
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center