Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Psychiatry. 2001 Jul;158(7):1140-2.

Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum.

Author information

1
Department of Psychiatry, University Hospital Utrecht, The Netherlands. w.staal@psych.azu.ne

Abstract

OBJECTIVE:

This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia.

METHOD:

Intracranial volume and volumes of the cerebrum, gray and white matter, lateral and third ventricles, frontal lobes, thalamus, and cerebellum were measured in 20 patients with a poor outcome, 25 with a favorable outcome, and 23 healthy comparison subjects with magnetic resonance imaging.

RESULTS:

Thalamic volume was significantly smaller both in poor-outcome patients and good-outcome patients. In contrast, only poor-outcome patients displayed significantly smaller cerebral gray matter, particularly prefrontal, and enlargement of the lateral and third ventricles. No significant differences were found for intracranial, cerebellar, or cortical CSF volumes.

CONCLUSIONS:

Smaller thalamic volumes in schizophrenia may reflect a greater susceptibility for the disorder and seem unrelated to outcome. In contrast, gray matter volume loss of the cerebrum, particularly in the frontal lobes, and lateral and third ventricular enlargement appear related to outcome in schizophrenia.

PMID:
11431237
DOI:
10.1176/appi.ajp.158.7.1140
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center