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Trends Immunol. 2001 Jul;22(7):400-5.

Ig heavy-chain gene revision: leaping towards autoimmunity.

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Temple University School of Medicine, Dept of Microbiology and Immunology, 3400 N. Broad St., Philadelphia, PA 19140, USA.


B cells can revise their antigen receptors outside the confines of the bone marrow by secondary Ig gene rearrangements. Although the initial motivation to perform these revisions might be to silence a self-reactive specificity, those B cells that reinitiate the recombination process can perform a series of "leaping" rearrangements and inadvertently shift their receptor specificity towards autoimmunity. Heavy-chain receptor revision, coupled with other atypical rearrangements, might contribute to autoantibody production in systemic lupus erythematosus.

[Indexed for MEDLINE]

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