Format

Send to

Choose Destination
Trends Immunol. 2001 Jul;22(7):394-400.

Dendritic cells as a tool to induce anergic and regulatory T cells.

Author information

1
Dept of Dermatology, University of Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany.

Abstract

The induction of antigen-specific T-cell tolerance in the thymus and its maintenance in the periphery is crucial for the prevention of autoimmunity. As well as their stimulatory functions, there is growing evidence that dendritic cells, acting as professional antigen-presenting cells, also maintain and regulate T-cell tolerance in the periphery. This control function is exerted by certain maturation stages and subsets of different ontogeny, and can be influenced by immunomodulatory agents. What is the current state of knowledge of the "immunoregulatory" properties of dendritic cells and how might tolerance-inducing dendritic cells be relevant to therapeutic applications in humans?

Comment in

PMID:
11429324
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center