Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2001 Jul;22(7):345-8.

Hemolytic uremic syndrome: how do factor H mutants mediate endothelial damage?

Author information

1
Hans Knoell Institute for Natural Products Research, Dept of Infection Biology, Beutenbergstr. 11, 07745 Jena, Germany. zipfel@pmail.hki-jena.de

Abstract

Hemolytic uremic syndrome is characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. Data from recent genetic analyses reveal a clear association between the complement regulator factor H and the atypical form of this fatal human disease. The clustering of the identified mutations in the C-terminus of factor H identifies a "hot spot" that is central to the pathogenesis of the disease. What are the possible biological and functional consequences of the identified mutations for the disease process and mechanisms of disease progression?

PMID:
11429311
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center