Send to

Choose Destination
See comment in PubMed Commons below
Biomed Pharmacother. 2001 Jun;55(5):277-83.

Determination, activity and biological role of adenylosuccinate lyase in blood cells.

Author information

  • 1Istituto di Biochimica e di Enzimologia, Universit√† di Siena Complesso Nuovi Istituti Biologici, Italy.


Adenylosuccinate lyase deficiency, which is associated with severe mental retardation and autistic features, was discovered in 1984. Since then this enzyme has been analyzed in many human tissues and it is now generally agreed that screening for this enzyme defect should be performed in all unexplained neurological diseases. The aim of the present study was to analyze adenylosuccinate lyase activity in blood cells by a fast simple method adaptable to screening purposes. The activity was also analyzed in B-lymphocytes from patients with B-cell chronic lymphocytic leukemia. The biological role of adenylosuccinate lyase and its importance in regulating cellular levels of AMP is discussed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center