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Trends Mol Med. 2001 Jan;7(1):18-22.

Molecular regulation of lymphangiogenesis and targets for tissue oedema.

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Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, University of Helsinki, P.O.B. 21 (Haartmaninkatu 3), 00014 Helsinki, Finland. Marika.Karkkainen@Helsinki.Fl


New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth factors-C and -D have been shown to stimulate lymphangiogenesis, and their receptor VEGFR-3 has been linked to human hereditary lymphoedema, although there is evidence that other genes are also involved. These data suggest that it may become possible to stimulate lymphatic growth and function and to treat tissue oedema involved in many diseases.

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