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Oncogene. 2000 Dec 27;19(56):6651-9.

Potential roles of antisense technology in cancer chemotherapy.

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Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA.


Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of exceptional value in the functionalization of genes and their validation as potential targets for cancer chemotherapy. Additionally, there is now substantial evidence that antisense drugs are safe, and a growing body of data showing activity in animal models of human disease including cancer, and suggesting efficacy in patients with cancer. In this article, I review the progress in the technology, the anticancer antisense drugs in development and potential roles that antisense technology might play.

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