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Neurology. 2001 Jun 26;56(12):1751-3.

Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke.

Author information

1
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. tscammel@caregroup.harvard.edu

Abstract

Idiopathic narcolepsy usually results from a loss of the hypothalamic neuropeptide orexin (hypocretin), but the cause of secondary narcolepsy resulting from focal brain lesions is unknown. The authors describe a young man who developed narcolepsy after a large hypothalamic stroke. His lesion included much of the hypothalamic region in which orexin is produced, and his CSF concentration of orexin was low. The authors hypothesize that a loss of orexin neurons or their relevant targets may be the specific neuropathology causing this and many other cases of secondary narcolepsy.

PMID:
11425947
DOI:
10.1212/wnl.56.12.1751
[Indexed for MEDLINE]

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