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Neurology. 2001 Jun 26;56(12):1749-51.

Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.

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Max Planck Institute of Psychiatry, Munich, Germany.

Erratum in

  • Neurology 2002 Jan 22;58(2):334.


Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.

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