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Bioorg Med Chem Lett. 2001 Jul 9;11(13):1779-82.

Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.

Author information

1
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via Aldo Moro, 53100, Siena, Italy. svaini@unisi.it

Abstract

Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed.

PMID:
11425559
DOI:
10.1016/s0960-894x(01)00294-3
[Indexed for MEDLINE]

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