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Bioorg Med Chem Lett. 2001 Jul 9;11(13):1737-40.

Isoindolines: a new series of potent and selective endothelin-A receptor antagonists.

Author information

1
Metabolic and Cardiovascular Diseases, Novartis Institute for Biomedical Research, 07901, Summit NJ, USA. paivi.kukkola@pharma.novartis.com

Abstract

1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET(A) selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure-activity relationships for both the trans and the cis series of isoindolines are discussed.

PMID:
11425549
DOI:
10.1016/s0960-894x(01)00273-6
[Indexed for MEDLINE]

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