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Bioorg Med Chem Lett. 2001 Jul 9;11(13):1709-12.

Biphenyls as surrogates of the steroidal backbone. Part 1: synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls.

Author information

1
Medicinal Chemistry, Aventis, 102 route de Noisy, 93235 Cedex, Romainville, France. dominique.lesuisse@aventis.com

Abstract

In the course of a programme aimed at discovering new ligands of the estrogen receptor, we explored a series of substituted biphenyls. Their synthesis and binding affinity are described.

PMID:
11425543
DOI:
10.1016/s0960-894x(01)00267-0
[Indexed for MEDLINE]

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