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Bioorg Med Chem Lett. 2001 Jul 9;11(13):1671-3.

Novel sulfonate derivatives: potent antimitotic agents.

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1
Cancer Research, D47B, Building AP-10, Abbott Laboratories, 60064-6101, Abbott Park, IL, USA

Abstract

The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.

PMID:
11425534
[Indexed for MEDLINE]

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