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Electrophoresis. 2001 May;22(9):1669-76.

Identification of post-translationally modified proteins in proteome studies.

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1
Institut für Physiologische Chemie, Ruhr-Universität Bochum, Germany. Albert.Sickmann@ruhr-uni-bochum.de

Abstract

Proteome studies are powerful tools to solve many different problems in metabolism, signal transduction, drug discovery, and other areas of interest in life sciences. Up to now, high-sensitive methods for protein identification after two-dimensional gel electrophoresis using mass spectrometry are available. However, the identification of post-translational modifications after two-dimensional gel electrophoresis is still an unsolved problem. In this paper, we want to give several examples for the successful identification of post-translational modifications and point mutations.

[Indexed for MEDLINE]

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