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Diabetes Care. 2001 Jul;24(7):1264-9.

Predictors of delayed gastric emptying in diabetes.

Author information

1
Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia. karen.jones@adelaide.edu.au

Abstract

OBJECTIVE:

To define the predictors of the rate of gastric emptying in patients with diabetes.

RESEARCH DESIGN AND METHODS:

A total of 101 outpatients with diabetes (79 type 1 and 22 type 2) underwent measurements of gastric emptying of a solid/liquid meal (scintigraphy), upper gastrointestinal symptoms (questionnaire), glycemic control (blood glucose concentrations during gastric emptying measurement), and autonomic nerve function (cardiovascular reflexes).

RESULTS:

The gastric emptying of solid and/or liquid was delayed in 66 (65%) patients. Solid (retention at 100 min 64 +/- 3.2 vs. 50.2 +/- 3.6%, P < 0.005) and liquid (retention at 100 min 22.7 +/- 1.7 vs. 16.0 +/- 1.8%, P < 0.001) gastric emptying was slower in women than in men. Of all upper gastrointestinal symptoms (including nausea and vomiting), only abdominal bloating/fullness was associated with slower gastric emptying (P < 0.005). A multiple regression analysis demonstrated that both abdominal bloating/fullness and female sex were predictors of slower gastric emptying of both solids and liquids.

CONCLUSIONS:

We conclude that the presence of abdominal bloating/fullness but not any other upper gastrointestinal symptom is associated with diabetic gastroparesis and that gastric emptying is slower in diabetic women than in diabetic men.

PMID:
11423513
DOI:
10.2337/diacare.24.7.1264
[Indexed for MEDLINE]

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