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Eur J Cancer. 2001 Jul;37(10):1270-5.

Genetic pathways and histogenetic models of AIDS-related lymphomas.

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  • 1Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale, I-33081, Aviano, Italy. acarbone@cro.it

Abstract

Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.

PMID:
11423258
[PubMed - indexed for MEDLINE]
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