Format

Send to

Choose Destination
Int J Dermatol. 2001 Mar;40(3):185-8.

TNFalpha and IL-6 are mediators in the blistering process of pemphigus.

Author information

1
Department of Immunology, CBE, Universidad Autónoma de Zacatecas, Guadalupe, Zac. México.

Abstract

BACKGROUND:

Pemphigus is an autoimmune disease characterized by intraepidermal blisters induced by pemphigus IgG. In addition to autoantibodies, molecular mechanisms involved in acantholysis remain largely unknown. For this reason, we address a possible role of the inflammatory cytokines IL-6 and TNFalpha in pemphigus lesions.

METHODS:

Sixteen biopsies from patients with different types of pemphigus were studied by in situ hybridization using DNA fluorescent probes for IL-6 and TNFalpha mRNA.

RESULTS:

Fifty-six percent of lesional biopsies exhibited cytokine gene expression, which was poorly expressed in noninvolved skin. Deposits of TNFalpha and IL-6 were products of in situ transcription at the epidermal level.

CONCLUSIONS:

Inflammatory cytokine expression around the blister could play a mediator role in pemphigus lesions by increasing epithelial damage.

PMID:
11422521
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center