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Cephalalgia. 2001 Mar;21(2):84-9.

Ophthalmoplegic migraine: a recurrent demyelinating neuropathy?

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Institute of Neurological Sciences, Prince of Wales Hospital and the Faculty of Medicine, University of New South Wales, Sydney, Australia.


The demonstration by magnetic resonance imaging (MRI) scanning of thickening and enhancement of the cisternal part of the oculomotor nerve in patients diagnosed as "ophthalmoplegic migraine" prompts reconsideration of this uncommon disorder. The case histories of five patients, three male and two female, varying in age from 6 to 30 years, are presented here. Recurrent painful ophthalmoplegia started in infancy in two cases, childhood in two instances and adult life in one. One child had his first attacks at 3, 5 and 12 months of age, on each occasion 10 days after an injection of triple vaccine. The possibility of this condition being a recurrent demyelinating neuropathy is considered and its possible relationship to migraine explored.

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