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Res Microbiol. 2001 Apr-May;152(3-4):391-9.

Translational regulation by ABC systems.

Author information

1
Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226, USA. chakra@mcw.edu

Abstract

Elongation factor 3 is a cytosolic protein required by the fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates binding of EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.

PMID:
11421286
DOI:
10.1016/s0923-2508(01)01210-4
[Indexed for MEDLINE]

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