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Arch Pathol Lab Med. 2001 Jul;125(7):961-3.

Dura mater involvement in ochronosis (alkaptonuria).

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  • 1Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.


Clinical manifestations of alkaptonuria have been well described and are most commonly characterized by ochronosis or pigmentation of connective tissue. Sites most commonly involved in ochronosis include joints, heart, skin, and kidney. We describe a 66-year-old woman with a history of alkaptonuria who had widespread ochronosis. The dura mater showed extensive pigment deposition, which was evident both grossly and microscopically at autopsy. To our knowledge, description of dura mater involvement by ochronosis has not been previously reported in the literature.

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